Pulmonary Emphysema and Proteolysis
نویسنده
چکیده
The book's only general defect is the uneven quality, which is probably inevitable when editors must wring finished manuscripts from a large number of contributors who have a variety of other pressing professional concerns. Some authors have simply described the current state of their own research, without troubling to add the two or three literature review paragraphs which establish the historical and related-area perspective necessary to a first rate reference work. An annoying specific detect is the inadequacy of the book's index, which is short and consists mostly of drugs names. Defects and all, the book is the best available on its subject, and it is better than many similar works on other subjects familiar to me. Such volumes are an important part of the process of continuing education in a world where daily medical practice in any speciality must be reoriented to new technologies every few years. J. W. PRICHARD Department of Neurology Yale University School of Medicine
منابع مشابه
Human Alveolar Macrophage Proteolytic
The occurrence of emphysema in people deficient in alphai-antltrypsin and the production of emphysema in experimental animals with elastolytic enzymes suggest proteolysis as a mechanism for the development of emphysema. To investigate the possible role of pulmonary alveolar macrophages in the pathogenesis of emphysema, we measured elastase, acid protease, and elastaselike esterase activities in...
متن کاملPathogenic Mechanisms in Emphysema: From Protease Anti–Protease Imbalance to Apoptosis
In 1963, Laurel and Erickson reported their discovery of severe ┙1-antitrypsin (AAT) deficiency and its association with emphysema (Laurell & Erickson, 1963). Soon after, Gross and coworkers reported that emphysema was induced in rats by the intratracheal instillation of a proteolytic enzyme (Gross et al.,1965). These findings led to the proteolytic hypothesis of emphysema (Janoff, 1985) which ...
متن کاملProteolysis in the lung.
Pulmonary emphysema is a major component of the morbidity and mortality of chronic obstructive pulmonary disease (COPD), a condition that has become the fourth leading cause of death in the USA, and is becoming epidemic worldwide. Emphysema is defined as enlargement of peripheral airspaces of the lung including respiratory bronchioles, alveolar ducts and alveoli, accompanied by destruction of t...
متن کاملComparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema
BACKGROUND In patients with emphysema, invasive mechanical ventilation settings should be adjusted to minimize hyperinflation while reducing respiratory effort and providing adequate gas exchange. We evaluated the impact of pressure-controlled ventilation (PCV) and pressure support ventilation (PSV) on pulmonary and diaphragmatic damage, as well as cardiac function, in experimental emphysema. ...
متن کاملIsolation and characterisation of human pulmonary microvascular endothelial cells from patients with severe emphysema
BACKGROUND Loss of the pulmonary microvasculature in the pathogenesis of emphysema has been put forward as a credible alternative to the classical inflammatory cell driven proteolysis hypothesis. Mechanistic studies in this area have to date employed animal models, immortalised cell lines, primary endothelial cells isolated from large pulmonary arteries and non-pulmonary tissues and normal huma...
متن کاملMassive Emphysema and Pneumothorax Following Shoulder Arthroscopy under General Anaesthesia: A Case Report
The patient was a 61-year-old female with massive rotator cuff tear who had no history of smoking, COPD, asthma, or other pulmonary diseases. Four hours following shoulder arthroscopy, the patient developed progressive dyspnea, which was diagnosed as pneumothorax with subcutaneous emphysema extending to the neck and face. Chest tube was inserted promptly. The patient was discharged with a good ...
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 47 شماره
صفحات -
تاریخ انتشار 1974